The idea of establishing an Association for Crohn's Disease and Ulcerative Colitis in Cyprus first arose in 1993, when a group of patients and their families attempted to create such an organization. However, this effort was not successful.

In late 2000, the idea was revived during a meeting of a few patients and their friends. A year later, on December 10, 2001, the Association’s founding general assembly was held, attended by many patients with Crohn’s disease and ulcerative colitis. During this meeting, a provisional Board of Directors was elected, consisting of eight members—four patients with Crohn’s disease and four of their immediate relatives. The Board of Directors was responsible for registering the Association as a non-profit organization with the Ministry of the Interior and preparing it for the first General Assembly.

On August 2, 2002, the Association was officially registered as a nonprofit organization with the Ministry of the Interior under the name “Pan-Cyprus Association for Ulcerative Colitis and Crohn’s Disease.”